Wednesday, January 9, 2013

Oxygen Permeability, OTR of Contact Lenses Materials

Speaking of contact lenses, the most common thing we thought of is their contact' effect. Contact lenses correct vision by directly adhering to the surface of eye cornea to change diopter. Therefore, they possess a lot of unique merits comparing with frame glasses. For example, it applies no compression to nose bridge and ears, and is especially applicable to some special professions such as actor and athlete. Actually, the functions of contact lenses are not limit to the correction of shortsightedness, farsightedness and astigmatism. They have other functions such as treating color blindness and some ophthalmocace by medication absorption.

1. Material Requirements of Contact Lens
Wearers attach particular importance to the selection of lens material because it adheres directly to eye cornea. With the influence of advertisement, many wearers go in for lenses of high moisture content in selecting contact lenses. In their eyes, the higher the moisture content, the better the lens quality. In fact, the pursuit of higher moisture content is very wrong in contact lens selection. Wearers should also take secretory volume of tears, working and living environment into account. Actually, oxygen permeability of lenses is the most important index. The discomforts and wearing time mainly depends on lens oxygen permeability. Moreover, higher moisture content and ultra thin that are advertised now are to improve lens oxygen permeability.

http://www.labthink.cn/en/product-info-oxygen-transmission-rate-test-system-ox2-230.html
OX2/230 Oxygen Permeability Tester

Oxygen deficit, which is caused by inability of eye cornea to obtain oxygen, is the most common trouble of wearing contact lenses. Originally, cornea breathes by obtaining oxygen from air directly. When contact lens adheres to eyeball surface, oxygen can still transmits through lenses, but the transmitting rate reduces obviously. Newly increased vessel caused by cornea oxygen deficit will appear as red heron and will increase the opportunity of infection of eyes. For that reason, contact lenses of higher oxygen permeability should be selected. Oxygen permeability of lenses is related with lens moisture content and lens thickness because oxygen is transmitted by water. However, the crucial factor that influences wearing effect is whether contact lenses match eye cornea.

As mentioned above, oxygen permeability of contact lenses has a direct influence on wearer comforts and will in turn affect the sales. That is why oxygen permeability testing attracts particular attention of lens manufacturers.
ISO issued special testing standards for the oxygen permeability testing of contact lenses: ISO 9913-1 Optics and Optical Instruments-Contact Lenses-Part 1: Determination of Oxygen Permeability and Transmissibility with the FATT Method and ISO 9913-2 Optics and Optical Instruments -Contact Lenses-Part2: Determination of Oxygen Permeability and Transmissibility by the Coulometric Method. Testing principal and testing instruments in ISO 9913-2 is very similar to that used in coulometric method in oxygen permeability testing of flexible material. Many manufacturers of contact lens have been authorizing Labthink to test the oxygen permeability of lens materials and have got ideal testing results.
ISO 9913-2 is suitable for rigid and non-hydrogel flexible contact lens materials. The testing indexes are oxygen flux-j, oxygen permeability -Dk, oxygen transmissibility-Dk/t and specimen thickness-t. Generally, Dk is used to evaluate the permeability index of contact lenses. Testing principle is illustrated as fig. 1: put specimen into testing chamber to divide the chamber into upper and lower parts. Fill testing gas into upper chamber with the oxygen content at a fixed rate. Carrier gas flows into coulometric sensor from lower chamber, by which an equal pressure between two sides of the specimen is maintained. However, oxygen partial pressure is different. Under the function of partial pressure, oxygen will transmits into carrier gas through film and will be carried into coulometric sensor, where oxygen quantity in nitrogen gas can be calculated accurately and then oxygen transmissibility of the material can be calculated. Oxygen permeability instrument should be calibrated with reference film before testing to determine the calibration factor, which will be used in calibration. It is regulated in standard ISO 9913 that calibration specimen SRM 1470 is the same as that used in standard ASTM D 3985 for film testing.
Testing process includes the following steps: purge system, diverge oxygen gas into upper chamber, sensor output becomes stable (judging whether transmitting achieves equilibrium), and obtain testing result. There are mainly two differences between testing of contact lenses and flexible package testing: one is the specimen fixture, specimen shape and area; the second difference is testing environment. Testing temperature of film oxygen permeability is 23. To simulate practical service condition, testing temperature of contact lenses is 35. Since temperature fluctuation has an obvious influence on testing results of oxygen permeability, the stability of testing temperature is of great significance. Therefore, it is better that the instruments possess function of temperature controlling, just as Labthink OX2/230 Oxygen PermeabilityTester.

3. Influence of Lenses Suitability on Oxygen Permeability

http://www.labthink.cn/en/product-index-oxygen-permeability-tester.html
OX2/230 Oxygen Permeability Tester

Whether contact lenses are suitable mainly depends on the perfection of suitability.  A pair of good contact lenses should match with eye cornea perfectly. There is a layer of tear existing between contact lens and eye cornea, and is constantly flowing. The tears bring oxygen to cornea and take off waste substance. In this way, contact lenses will not change the normal physiological condition of eyes and will not impair eye cornea. If the contact lens doesn’t match well with eye cornea, even ultra thin lenses of high moisture content will adhere closely to the cornea with the result that the flowing of oxygen can only rely on moisture content and thickness of the lens. Of course, high oxygen permeability is always favorable, no matter what the kind of suitability is.

4. Conclusion
Oxygen permeability of contact lens, which has a direct influence on wearing comforts, is an important index. That is why manufacturers of various contact lenses are trying their best to improve oxygen permeability of contact lenses. At present, the marketing of PGP has obviously influenced market share of traditional flexible contact lenses. The outstanding merit of RGP is high oxygen permeability, which makes no oxygen deficit of eye cornea. With RGP, many complications caused by flexible contact lenses can be avoided. Therefore, RGP has become known and encouraged by most experts.

Tuesday, January 8, 2013

Transit Package Testing for Cosmetics

As fashionable products, cosmetics need exquisite packages and best protection during Transit and shelf-life time. Labthink Instruments Co. Ltd. (www.labthink.cn), the world famous testing instrument and service provider, meets the demands for cosmetics packaging and application, integrates testing items and instruments as follows, so as to contribute to the package quality testing of cosmetics companies and relevant package suppliers.

The cosmetics products should reach the customers in good condition after transit, shelf display and other procedures. Now, the transit packages of cosmetics are mainly corrugated paper boxes, and the main testing indexes are compression strength and stacking testing of plastic boxes.




1. Compression Strength Testing for Corrugated Paper Boxes: We hereby take Labthink XYD-15K Box Compression Tester for introduction. When testing, place the corrugated box in between the compression plates of XYD-15K Box Compression Tester; and then, set the speed and start the test until the occurrence of box breakage. The pressure is the compression strength in kN. When doing such tests, a preset pressure, normally 220N, is a must before testing. 

XYD-15K Box Compression Tester
2. Stacking Tests of Corrugated Boxes: During Transportation, corrugated boxes needs to be stored in the form of stack. The boxes at the bottom endure more pressure than the upper ones. In order to avoid collapse, proper compression strength is needed when stacking. Therefore, stacking testing and maximum compression strength are of great importance. Labthink XYD-15K Box Compression Tester has stack testing function, and can output stacking test result directly.





Labthink, the excellent provider of testing instruments and testing services, is devoted to provide most excellent and complete quality control solutions for pharmaceutical, foodstuff, cosmetics, packaging, printing, adhesive, automotive, petrochemistry, environment, biology, new energy, construction, aviation and electronic industries worldwide.

Detailed information,pls contact Emily Wu via trade12@labthink.cn or the telephone:0086-531-85060139.

Monday, January 7, 2013

Oxygen Transmission Rate Testing Equipment-OTR Tester


Oxygen Transmission Rate Testing Equipment-OTR Tester professionally designed for the determination of oxygen transmission rate test of film and package specimens. It has three test modes and is applicable to various materials with high, medium and low oxygen permeability. Oxygen Transmission Rate Testing Equipment-OTR Testeris also embedded with high precision oxygen sensor, which provides a huge test range of 0.01~65000cm3/m2·d and durable service life.
  • Wide range and high precision of temperature and humidity control, adding humidity to two sides of the specimen, to support various combinations of non-standard test conditions
  • World leading pressure compensation technology ensures accurate and repeatable test results
  • Standard, proportional and continuous testing modes facilitate to minimize errors caused by human factors during the testing process
  •  
  • Save test data in different formats for convenient data transfer



http://www.labthink.cn/en/product-info-oxygen-transmission-rate-test-system-ox2-230.html
Oxygen Transmission Rate Testing Equipment

Applications:
  • Films
  • Sheeting
  • Packages
  • Solar Back-Sheets
  • Battery Plastic Shell

Technical Specifications:
  • Number of Specimens:1~3 with independent test results
  • Temperature Range:15°C~55°C (standard)
  • 
  • Temperature Accuracy:±0.1°C (standard)
  • Humidity Accuracy:±1%RH
  • Carrier Gas Pressure:≥ 0.28MPa


Oxygen Transmission Rate Testing Equipment-OTR Tester conforms to the following standards:
ISO 15105-2, GB/T 19789, ASTM D3985, ASTM F2622, ASTM F1307, ASTM F1927, JIS K7126-2, YBB00082003


http://www.labthink.cn/en/product-index-oxygen-permeability-tester.html
OTR Tester

D3985 Standard Test Method for Oxygen Gas Transmission Rate Through Plastic Film and Sheeting Using a Coulometric Sensor



F2622 Standard Test Method for Oxygen Gas Transmission Rate Through Plastic Film and Sheeting Using Various Sensors







Moisture Vapor Transmission Rate Testing Instrument

Moisture Vapor Transmission Rate Testing Instrument-ASTM F1249-06 Standard Test Method for Water Vapor Transmission Rate Through Plastic Film and Sheeting Using a Modulated Infrared Sensor

Moisture Vapor Transmission Rate Testing Instrument is designed for the determination of water vapor transmission rate test of film and package specimens. It has three test modes and is applicable to various materials with high, medium and low water vapor permeability. It is also embedded with high precision infrared sensor, which provides a wide test range of 0.001~1000g/m2·24h and durable service life.
     
    http://www.labthink.cn/en/product-info-water-vapor-transmission-rate-test-system-w3-230.html
    Moisture Vapor Transmission Rate Testing Instrument
    
  • Wide range and high-precision of automatic temperature and humidity control to support various combinations of non-standard test conditions
  • Proportional, cycling and manual testing modes facilitate to test different materials with distinct water vapor permeability
  • Save test data in different formats for convenient data transfer
  • The system can be easily connected to a maximum of 10 instruments to accomplish up to 30 tests at the same time
Applications:
  • Films
  • Sheet
  • Paper and Paper Board
  • Packages
  • Pharmaceutical Blister Package
  • Instant Noodles, Paper Cups and Bowls

Technical Specifications:
  • Number of Specimen:3 (Independent results for each specimen)
  • Temperature Range:15°C~55°C (standard)
  • Temperature Accuracy:±0.1°C (standard)
  • 
  • Pressure of Carrier Gas:0.28MPa/40.6psi



Moisture Vapor Transmission Rate Testing Instrument conforms to the following standards:
ISO 15106-2, ASTM F1249, TAPPI T557, JIS K7129


Labthink,Think for you only!


http://www.labthink.cn/en/product-info-water-vapor-transmission-rate-test-system-w3-230.html
W3/230 WVTR Tester


Friday, January 4, 2013

Introduction for Ampoule bottles’ Headspace Analysis Detection Methods

Ampoule bottle’s headspace analysis (especially the residual oxygen analysis ) related to the quality stability of powder-injection, water injection, infusion bottle and oral liquid in product warranty period. Through Labthink’s HGA-01 Headspace gas analyzer and its dedicated sampler can conveniently and efficiently solve the residual oxygen detection problem and make small-volume ampoule bottle and other packaging detecting achieve good result.

1.Why we must control ampoule bottle’s residual oxygen content of the headspace gas
Oxygen is the main factor to influence the product warranty period of powder injection, water injection and oral liquid. It was found that by control the gas proportion of the packaging can effectively prolong the product shelf life or improve the reservation quality. Nowadays some products’ packages such as powder injection, water injection and oral liquid, mainly adopt ampoule bottle’s packaging way.  After filling there will be a little gas remaining in the bottle, So the actual gas composite in the package bottle is different from expected, which take some difficulty in analyzing product quality, expected validity of warranty life and rationality of the packaging design .By HGA-01 Headspace Gas Analyzer produced by Labthink can effectively solve the gas composition problem in ampoule bottle. Now it had become an important means to check the drug design’s quality and one of the important ways to verify the product warranty.

2. Detecting difficulties in ampoule bottle’s Headspace gas analysis

Amboule Bottle

Residual oxygen is an important point in headspace gas analysis, but the integral volume of common ampoule bottle package such as powder injection, water injection and oral liquid is small, and the headspace gas volume of ampoule bottle is less. The common headspace analyzing equipment can’t carry the analyzing test of gas collection amount which is less than 0.5ml and 0.2ml.And this is also the detecting difficulty of headspace gas analyzer for small volume packaging such as ampoule bottles.


3. Choose the appropriate Headspace Gas Analyzer HGA-01

Now some headspace gas analyzer on the market basically cannot complete the residual oxygen analysis of water injection and powder injection and other medicine.HGA-01 Headspace Gas Analyzer produced by Labthink can solve the above difficulties through the specialized sampler, which can make small package headspace gas analysis detection realized.HGA-01 Headspace Gas Analyzer absorb the advantage of desktop and portable equipment, and also have many unique advantages. Firstly, It can test oxygen and dioxide simultaneously, while the range and accuracy reach to the first-class in the international world. Secondly, it has annual and automatic operating mode and test oxygen and dioxide in the meantime.
Configure dedicated needlegaskets and filters, get great improvement in exhaust time and response time ,which can totally ensure the reality and effectiveness of the testing data.
In addition, the instrument is equipped with the current international mainstream gas analyzer sensors, which can guarantee six years normal use. To facilitate the instrument have the portable and  hand function, and have the printing function which the traditional equipment don’t have
which can make it conveniently used in various environments and have rapid detection for the sample.

4. Ampoule bottle residual oxygen analysis detection summary

http://www.labthink.cn/en/product-info-headspace-gas-analyzer-hga-01.html
HGA-01 Headspace Gas Analyzer


The detection analysis for the headspace gas residual oxygen can make us control the packaging change of internal gas component for powder-injection, water-injection and oral liquid more conveniently, accurately and rapidly, and also the important data support for analysis of product quality, effectiveness of shelf life and rationality of packaging design and be an essential testing ways to strengthen the product quality control, the practical and reliable HGA-01 Headspace Gas Analyzer with dedicated procurement sampler equipment is the basis to have residual analysis control for more pharmaceutical companies.

More about the detailed information for pharmaceutical headspace gas analyzer, pls contact Emily for 0531-85060139 or go on the web: www.labthink.cn for inquiry.